Β桶状结构

β桶状结构(英语:Beta barrel)是蛋白质的一种三级构造。它由多条β折叠带通过反平行重叠成桶状,两段则由肽链残基间的氢键结束。常见采取这种构造的蛋白有孔蛋白、跨膜蛋白以及其他需要与非极性分子打交道的蛋白。

在β桶中,β折叠带往往同时带有亲水与疏水性残基。根据外部环境与管道需要,再将内外分别整理成亲水或疏水的管道面。

参考文献
外部链接
*[http://www.cryst.bbk.ac.uk/PPS95/course/8_folds/all_beta.html Explanation of all-beta topologies] : "orthogonal beta-sandwiches" are beta-barrels (as defined in this article); "aligned" beta-sandwiches" correspond to beta-sandwich folds in SCOP classification.
*[https://web.archive.org/web/20120509122609/http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.c.html all-beta folds in SCOP database] (folds 54 to 100 are water-soluble beta-barrels).
*[http://www.cathdb.info/cathnode/2.40 CATH database - folds and homologous superfamilies within the beta-barrel architecture.]
*[https://web.archive.org/web/20060914195139/http://kinemage.biochem.duke.edu/~jsr/index.html General classification and images of protein structures from Jane Richardson lab]
*[http://www.biologie.uni-konstanz.de/folding/Structure%20gallery%201.html Images and examples of transmembrane beta-barrels]
*[https://web.archive.org/web/20120204132129/http://www.sbc.su.se/~gvh/teaching/SweLL/module1.html Stockholm Bioinformatics Center review of transmembrane proteins]
*[https://web.archive.org/web/20060903014158/http://www.jenner.ac.uk/Lipocalin/frontpage.htm The Lipocalin Website]
*The OMPdb database for beta-barrel proteins

评论 (0)

  • 还没有评论,来抢沙发吧。