9-甲基鸟嘌呤
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喷昔洛韦(Penciclovir)是鸟嘌呤类似物类抗病毒药物, 用于治疗多种疱疹病毒感染。具有毒性低,病毒敏感性高等特点。喷昔洛韦口服吸收低,常用于局部给药。 泛昔洛韦是喷昔洛韦的前药,口服吸收好。 作用机理和选择性 喷昔洛韦原型对病毒没有作用。在病毒感染的细胞中,喷昔洛韦被脱氧胸苷激酶磷酸化为三磷酸喷昔洛韦。三磷酸化物能抑制病毒DNA聚合酶,从而影响病毒在细胞内的复制。 喷昔洛韦的选择性可能来自于两个原因。首先是在正常细胞中,喷昔洛韦…
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