头孢尼西

{{Drugbox
| Watchedfields = changed
| verifiedrevid = 443509375
| IUPAC_name = (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetyl)amino]-8-oxo-
3-{[1-(sulfomethyl)tetrazol-5-yl]sulfanylmethyl}-
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
| image = cefonicid.png

| tradename =
| Drugs.com =
| MedlinePlus = a601206
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =

| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =

| CAS_number = 61270-58-4
| ATC_prefix = J01
| ATC_suffix = DC06
| PubChem = 43594
| DrugBank_Ref =
| DrugBank =
| ChemSpiderID_Ref =
| ChemSpiderID = 39734
| UNII_Ref =
| UNII = 6532B86WFG
| KEGG_Ref =
| KEGG = D07644
| ChEBI_Ref =
| ChEBI = 3491
| ChEMBL_Ref =
| ChEMBL = 1601

| C=18 | H=18 | N=6 | O=8 | S=3
| smiles = O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C@Hc3ccccc3)CSc4nnnn4CS(=O)(=O)O)C(=O)O
| StdInChI_Ref =
| StdInChI = 1S/C18H18N6O8S3/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32)/t11-,13-,16-/m1/s1
| StdInChIKey_Ref =
| StdInChIKey = DYAIAHUQIPBDIP-AXAPSJFSSA-N
}}

头孢尼西（英语：Cefonicide或Cefonicid）是头孢菌素抗生素。

__TOC__
合成
与头孢孟多相关的注射用半合成头孢菌素抗生素，q.v.

通过用适当取代的四唑硫醇 (2) 亲核置换 (1) 的 3-乙酰氧基部分可以方便地合成头孢尼西。扁桃酸酰胺C-7侧链让人联想到头孢孟多。

参见

• 头孢氮氟

参考资料