头孢匹罗

{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 447915116
| IUPAC_name = 1-{[(6R,7R)-7-[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-5H,6H,7H-cyclopenta[b]pyridin-1-ium
| image = Cefpirome.svg

| tradename =
| Drugs.com =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =

| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =

| CAS_number_Ref =
| CAS_number = 84957-29-9
| ATC_prefix = J01
| ATC_suffix = DE02
| PubChem = 6917674
| DrugBank_Ref =
| DrugBank =
| ChEMBL_Ref =
| ChEMBL = 2106076
| UNII_Ref =
| UNII = S72Q2F09HY
| KEGG_Ref =
| KEGG = D07649
| ChemSpiderID_Ref =
| ChemSpiderID = 23089536
| smiles = CON=C(c1csc(n1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[n+]4cccc5c4CCC5)C(=O)[O-]
| StdInChI_Ref =
| StdInChI = 1S/C22H22N6O5S2/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32)/b26-15-/t16-,20+/m1/s1
| StdInChIKey_Ref =
| StdInChIKey = DKOQGJHPHLTOJR-XECLGWKCSA-N

| C=22 | H=22 | N=6 | O=5 | S=2
}}
头孢匹罗（英语：Cefpirome）是第四代头孢菌素，商品名包括Cefrom、Keiten、Broact和Cefir。头孢匹罗被认为对革兰氏阴性菌（包括铜绿假单胞菌）和革兰氏阳性菌具有高度活性。

细菌敏感性和耐药性谱
脆弱拟杆菌、肠球菌、假单胞菌和葡萄球菌对硫酸头孢匹罗耐药，一些嗜血杆菌属物种对硫酸头孢匹罗耐药。肺炎球菌已对其产​​生不同程度的耐药性。

参考资料