甲碸黴素

{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 470606287
| IUPAC_name = 2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide
| image = Thiamphenicol_stereo.png
| width = 214
| image2 = Thiamphenicol_sf.gif

| tradename =
| Drugs.com =
| pregnancy_category = ?
| legal_status = none
| routes_of_administration = IV, IM, oral

| bioavailability = ?
| metabolism = hepatic
| elimination_half-life = 5.0 hours
| excretion = renal

| CAS_number_Ref =
| CAS_number = 15318-45-3
| ATC_prefix = J01
| ATC_suffix = BA02
| ATC_supplemental =
| PubChem = 27200
| DrugBank_Ref =
| DrugBank = DB08621
| ChemSpiderID_Ref =
| ChemSpiderID = 25315
| UNII_Ref =
| UNII = FLQ7571NPM
| KEGG_Ref =
| KEGG = D01407
| ChEBI_Ref =
| ChEBI = 32215
| ChEMBL_Ref =
| ChEMBL = 1236282

| C=12 | H=15 | Cl=2 | N=1 | O=5 | S=1
| molecular_weight = 356.223 g/mol
| smiles = ClC(Cl)C(=O)NC@@Hc1ccc(cc1)S(=O)(=O)C)CO
| InChI = 1/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
| InChIKey = OTVAEFIXJLOWRX-NXEZZACHBV
| StdInChI_Ref =
| StdInChI = 1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
| StdInChIKey_Ref =
| StdInChIKey = OTVAEFIXJLOWRX-NXEZZACHSA-N
}}
甲碸黴素，又名硫黴素、甲碸氯黴素或賽芬妥黴素，是一種酰胺醇类抗生素。它是氯黴素的甲基磺酰基类似物，有著相似的反應，强度却小2.5－5倍。與氯黴素相似，甲碸黴素不溶於水，但卻极易溶於脂類。与氯黴素相比，甲碸黴素的主要优点是不會引起再生不良性貧血。

应用
许多國家主要将甲碸黴素用于獸药，但在中國及意大利该抗生素还可以用于人類疾病的治疗。在巴西，甲碸黴素的应用也十分广泛，特别是用于治疗性传播疾病及盆腔炎。

参考文献
外部連結
*[http://www.fao.org/docrep/W4601E/w4601e0d.htm Overview at World Health Organization - Food and Agriculture Organization]
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