左西替利嗪

{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 464192413
| IUPAC_name = 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
| image = Levocetrizine Structural Formulae.png
| width = 280
| image2 = Levocetirizine 3D ball.png
| alt2 = Ball-and-stick model of the levocetirizine molecule

| tradename = Xyzal, Levazyr
| Drugs.com =
| MedlinePlus = a607056
| pregnancy_AU =
| pregnancy_US = B
| pregnancy_category =
| legal_AU =
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = Oral

| bioavailability = 高
| protein_bound = 90%
| metabolism = 肝臟 14% CYP3A4
| elimination_half-life = 6 至 10 小時
| excretion = 腎及排泄物

| CAS_number_Ref =
| CAS_number = 130018-77-8
| ATC_prefix = R06
| ATC_suffix = AE09
| PubChem = 1549000
| IUPHAR_ligand = 1214
| DrugBank_Ref =
| DrugBank =
| ChemSpiderID_Ref =
| ChemSpiderID = 1266001
| UNII_Ref =
| UNII = 6U5EA9RT2O
| KEGG_Ref =
| KEGG = D07402
| ChEMBL_Ref =
| ChEMBL = 1201191

| C=21 | H=25 | Cl=1 | N=2 | O=3
| molecular_weight = 388.888 g/mol
| smiles = Clc1ccc(cc1)C@HO)CC2)c3ccccc3
| StdInChI_Ref =
| StdInChI = 1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
| StdInChIKey_Ref =
| StdInChIKey = ZKLPARSLTMPFCP-OAQYLSRUSA-N
}}

左西替利{{ruby|嗪|-{zh-hans:qín;zh-tw:ㄑㄧㄣˊ;zh-hk:ceon4}-}}（），又稱：Xyzal、驅異樂。是第二代抗組織胺藥，衍生自第二代抗組織胺藥鹽酸西替利嗪，為鹽酸西替利嗪外消旋混合物的左對映異構體。

醫療用途
鹽酸左西替利嗪用於過敏症狀，包括流淚、流鼻涕、打噴嚏，蕁麻疹及瘙癢。

副作用
常見的副作用有頭痛、嗜睡、口乾、疲勞，發生機率等於或高於1%。

*長期吃抑制時效明顯變短，效力變差。
*此外全身或背部可能會出現針刺痛癢的短暫感覺。

相關製劑
其與盐酸形成二盐酸盐——盐酸左西替利嗪（Levocetirizine Dihydrochloride）为常见的市售药物形式。

註釋
參考文獻
*[http://www.gsk.tw/PDF/medicines/Xyzal.pdf Xyzal 驅異樂 全仿單]

參見
*
*WebMD
*複方藥

外部連結

• [http://www.ucb.com/_up/ucb_com_products/documents/Xyzal_PI_%2012_2010.pdf Full US prescribing information Xyzal® (levocetirizine dihydrochloride) tablets and oral solution (provided by UCB, December 2010, pdf file)]