头孢孟多

{{Drugbox
| Watchedfields = changed
| verifiedrevid = 443508077
| IUPAC_name = (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-
3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
| image = Cefamandole.svg

| tradename = former Mandol
| Drugs.com =
| MedlinePlus = a601206
| pregnancy_AU = B1
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK = POM
| legal_US =
| legal_US_comment = Discontinued
| routes_of_administration = Intramuscular, intravenous

| bioavailability =
| protein_bound = 75%
| metabolism =
| elimination_half-life = 48 minutes
| excretion = Mostly renal, as unchanged drug

| CAS_number_Ref =
| CAS_number = 34444-01-4
| CAS_supplemental =
| ATC_prefix = J01
| ATC_suffix = DC03
| PubChem = 456255
| DrugBank_Ref =
| DrugBank = DB01326
| ChemSpiderID_Ref =
| ChemSpiderID = 401748
| UNII_Ref =
| UNII = 5CKP8C2LLI
| KEGG_Ref =
| KEGG = D02344
| ChEBI_Ref =
| ChEBI = 3480
| ChEMBL_Ref =
| ChEMBL = 1146

| C=18 | H=18 | N=6 | O=5 | S=2
| smiles = O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C@Hc3ccccc3)CSc4nnnn4C)C(=O)O
| StdInChI_Ref =
| StdInChI = 1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1
| StdInChIKey_Ref =
| StdInChIKey = OLVCFLKTBJRLHI-AXAPSJFSSA-N
}}
头孢孟多酯（Cefamandole、Cefamandole Nafate），是一款先鋒黴素廣譜抗生素。

药物学特点
别名与生产
头孢孟多甲酯钠、头孢孟多、Kefadol、Neocefal。

药理作用
本药通过与细菌细胞膜上的PBPs结合，使细菌细胞分裂与生长受到抑制，从而起杀菌作用。其经肌内或静脉给药后在体内迅速水解为头孢孟多。

适应证
适用于治疗敏感菌所致的各类感染如皮肤软组织感染、呼吸道感染及败血症等。

临床须知
链接

• 抗生素
• 第二代头孢菌素

参考资料
临床抗菌药物实用指南 ，ISBN 978-7-5357-4849-2