地可谷兰

{{Drugbox
| IUPAC_name = 5-({7-(Trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}ethynyl)-2-pyridinamine
| image = Decoglurant structure.svg
| CAS_number = 911115-16-7
| UNII_Ref =
| UNII = 5VX4P0JKC5
| ATC_prefix = none
| ATC_suffix =
| PubChem = 71533696
| DrugBank =
| ChemSpiderID = 32695160
| KEGG = D10875
| C=21 | H=11 | F=6 | N=5
| smiles = C1=CC(=CC=C1C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C#CC4=CN=C(C=C4)N)C(F)(F)F
| StdInChI = 1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29)
| StdInChIKey = DMJHZVARRXJSEG-UHFFFAOYSA-N
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status = 中止研发
| routes_of_administration =
}}

地可谷兰（INN：decoglurant；开发代号：RG1578、RO4995819）是一种mGlu2和mGlu3受体的负变构调节剂，由罗氏公司开发，用于辅助治疗重度抑郁症。地可谷兰已进入II期临床试验，

参见

• 巴昔谷兰
• RO4491533

参考资料
外部链接

• [http://adisinsight.springer.com/drugs/800034342 Decoglurant – AdisInsight – Springer]