阿卡替尼

{{Infobox drug
| drug_name =
| INN =
| type =
| image = Acalabrutinib.svg
| width =
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| caption =

| pronounce =
| tradename = Calquence
| Drugs.com =
| MedlinePlus = a618004
| licence_CA =
| licence_EU =
| DailyMedID = Acalabrutinib
| licence_US =
| pregnancy_AU = C
| pregnancy_AU_comment =
| pregnancy_US = N
| pregnancy_US_comment =
| pregnancy_category=
| dependency_liability =
| addiction_liability =
| routes_of_administration = 口服
| class =
| ATCvet =
| ATC_prefix = L01
| ATC_suffix = EL02
| ATC_supplemental =

| legal_AU = S4
| legal_AU_comment =
| legal_BR =
| legal_BR_comment =
| legal_CA = Rx-only
| legal_CA_comment =
| legal_DE =
| legal_DE_comment =
| legal_NZ =
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| legal_UK =
| legal_UK_comment =
| legal_US = Rx-only
| legal_US_comment =
| legal_EU = Rx-only
| legal_EU_comment =
| legal_UN =
| legal_UN_comment =
| legal_status =

| bioavailability =
| protein_bound =
| metabolism =
| metabolites =
| onset =
| elimination_half-life =
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| CAS_number = 1420477-60-6
| CAS_supplemental =
| PubChem = 71226662
| IUPHAR_ligand =
| DrugBank = DB11703
| ChemSpiderID = 36764951
| UNII = I42748ELQW
| KEGG = D10893
| ChEBI = 167707
| ChEMBL = 3707348
| NIAID_ChemDB =
| PDB_ligand =
| synonyms = ACP-196

| IUPAC_name = 4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide
| C=26 | H=23 | N=7 | O=2
| SMILES = CC#CC(=O)N1CCC[C@H]1c2nc(c3n2ccnc3N)c4ccc(cc4)C(=O)Nc5ccccn5
| StdInChI = 1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
| StdInChI_comment =
| StdInChIKey = WDENQIQQYWYTPO-IBGZPJMESA-N
| density =
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}}
阿卡替尼（）是一种用于治疗各种类型的非霍奇金氏淋巴瘤的药物，包括被套细胞淋巴瘤（MCL）和慢性淋巴细胞白血病/小淋巴细胞白血病 （CLL/SLL）。

常见的副作用包括头痛、感觉疲倦、低红细胞、低血小板和低白细胞。阿卡替尼阻断布鲁顿酪氨酸激酶的酶，该酶有助于B细胞存活和生长。通过阻断这种酶，阿卡替尼有望减缓CLL中癌细胞 B 细胞的积聚，从而延缓癌症的进展。

副作用
最常见的不良反应是头痛、腹泻和体重增加。

参考文献
外部链接
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