尼氟滅酸

{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 457481224
| IUPAC_name = 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
| image = Niflumic acid.png

| tradename =
| Drugs.com =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =

| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life = 2.5 hr
| excretion =

| CAS_number_Ref =
| CAS_number = 4394-00-7
| ATC_prefix = M01
| ATC_suffix = AX02
| ATC_supplemental =
| IUPHAR_ligand = 2439
| DrugBank_Ref =
| DrugBank =
| ChEMBL_Ref =
| ChEMBL = 63323
| UNII_Ref =
| UNII = 4U5MP5IUD8
| KEGG_Ref =
| KEGG = D08275
| PubChem = 4488
| ChemSpiderID_Ref =
| ChemSpiderID = 4333
| smiles = C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
| StdInChI_Ref =
| StdInChI = 1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
| StdInChIKey_Ref =
| StdInChIKey = JZFPYUNJRRFVQU-UHFFFAOYSA-N

| C=13 | H=9 | F=3 | N=2 | O=2
| melting_point = 204
}}

尼氟灭酸（；别名尼氟酸、氟尼酸）是一种治疗关节和肌肉疼痛的药物。它被归类为环氧合酶-2的抑制剂。在实验生物学中，尼氟灭酸也应用于抑制。还有报道称，尼氟灭酸能够作用于GABA-A及NMDA受体通道，并能阻滞T-型钙离子通道。

参考资料