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傅嫈惠

Wikipedia · 2024-08-30 维基百科 👁 1 阅读

傅嫈惠（）是臺灣臺中豐原出身的美国華裔生物学家和人类遗传学家，國立中興大學食品科學、俄亥俄州立大學畢業，目前是加州大学旧金山分校的神经学教授，美国国家科学院院士。

生平
1980年取得国立中兴大学食品科学学位，1986年取得俄亥俄州立大学生物化学以及细胞生物学学位。之后，在俄亥俄州立大学和贝勒医学院从事了博士后研究，主要研究内容为人类基因组。她在业界工作过四年后，返回学术界担任犹他大学研究助理教授。2002年，在加州大学旧金山分校与合作者Louis Ptacek共同组建了实验室。

2018年，当选为美国国家科学院院士與中華民國中央研究院生命科學組院士。

部分出版物

Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptáček LJ, Fu Y-H. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Toh+KL%2C+Jones+CR%2C+He+Y%2C+Eide+EJ%2C+Hinz+WA%2C+Virshup+DM%2C+Pt%C3%A1%C4%8Dek+LJ%2C+Fu+Y-H.+An+hPer2+phosphorylation+site+mutation+in+familial+advanced+sleep-phase+syndrome.+Science.+2001%3B291%3A1040-3. An hPer2 phosphorylation site mutation in familial advanced sleep-phase syndrome]. Science. 2001;291:1040-3.

Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptáček LJ, Fu Y-H. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Xu+Y%2C+Padiath+QS%2C+Shapiro+RE%2C+Jones+CR%2C+Wu+SC%2C+Saigoh+N%2C+Saigoh+K%2C+Pt%C3%A1%C4%8Dek+LJ%2C+Fu+Y-H.+Functional+consequences+of+a%C2%A0CKI%CE%B4%C2%A0mutation+causing+familial+advanced+sleep+phase+syndrome.%C2%A0Nature.+2005%3B434%3A640-4. Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome]. Nature. 2005;434:640-4.

Padiath QS, Saigoh K, Schiffman R, Asahara H, Koeppen A, Hogan K, Ptáček LJ, Fu Y-H. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Padiath+QS%2C+Saigoh+K%2C+Schiffman+R%2C+Asahara+H%2C+Koeppen+A%2C+Hogan+K%2C+Pt%C3%A1%C4%8Dek+LJ%2C+Fu+Y-H.%C2%A0Lamin+B1%C2%A0duplications+cause+autosomal+dominant+leukodystrophy.%C2%A0Nat+Genet.+2006+Oct%C2%A0%3B+38(10)1114-23.+Epub+2006+Sep+3. Lamin B1][https://www.ncbi.nlm.nih.gov/pubmed/?term=Padiath+QS%2C+Saigoh+K%2C+Schiffman+R%2C+Asahara+H%2C+Koeppen+A%2C+Hogan+K%2C+Pt%C3%A1%C4%8Dek+LJ%2C+Fu+Y-H.%C2%A0Lamin+B1%C2%A0duplications+cause+autosomal+dominant+leukodystrophy.%C2%A0Nat+Genet.+2006+Oct%C2%A0%3B+38(10)1114-23.+Epub+2006+Sep+3. duplications cause autosomal dominant leukodystrophy]. Nat Genet. 2006 Oct ; 38(10)1114-23. Epub 2006 Sep 3.

He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. [https://www.ncbi.nlm.nih.gov/pubmed/?term=He+Y%2C+Jones+CR%2C+Fujiki+N%2C+Xu+Y%2C+Guo+B%2C+Holder+J%2C+Nishino+S%2C+and+Fu+Y-H.+Transcriptional+suppressor+DEC2+is+a+Regulator+for+Human+Sleep+Homeostasis.%C2%A0Science.+2009+325%3A866. Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis]. Science. 2009 325:866.

Fu, YH and Marzluf, GA. [https://www.ncbi.nlm.nih.gov/pubmed/?term=cys-3%2C+the+positive-acting+sulfur+regulatory+gene+of+Neurospora+crassa%2C+encodes+a+sequence-specific+DNA-binding+protein cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein]. J Biol Chem, 1990, 265, 11942-11947.

Fu, Y.H., Kuhl, D.P., Pizzuti, et al. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Variation+of+the+CGG+repeat+at+the+fragile+X+site+results+in+genetic+instability%3A+resolution+of+the+Sherman+paradox Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox]. Cell, 1991, 67, 1047-1058.

Fu, Y.H., Pizzuti, A., Fenwick, R.G., Jr., et al. [https://www.ncbi.nlm.nih.gov/pubmed/?term=An+unstable+triplet+repeat+in+a+gene+related+to+myotonic+muscular+dystrophy An unstable triplet repeat in a gene related to myotonic muscular dystrophy]. Science, 1992, 255, 1256-1258.

Yu, C.E., Oshima, J., Fu, Y.H., et al. [https://www.ncbi.nlm.nih.gov/pubmed/8602509 Positional cloning of the Werner's syndrome gene] . Science, 1996, 272, 258-262.

Levy‑Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu C, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wejsman EM, Bird TD, Schellenberg GD, Tanzi RE. [https://www.ncbi.nlm.nih.gov/pubmed/7638622 Candidate gene for the chromosome 1 familial Alzheimer's disease locus.] Science, 1995 269, 973-977.

Xu Y, Toh KL, Jones CR, Shin JY, Fu Y-H, Ptáček LJ. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Modeling+of+a+human+circadian+mutation+yields+insights+into+clock+regulation+by+PER2 Modeling of a human circadian mutation yields insights into clock regulation by PER2] . Cell*. 2007 Jan 12:128(1):59-70.

Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu Y-H. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Glucose+Sensor+O-GlcNAcylation+Coordinates+with+Phosphorylation+to+Regulate+Circadian+Clock Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock].Cell Metab*. 2013 Feb 5;17(2):291-302.

Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ. [https://www.ncbi.nlm.nih.gov/pubmed/23636092 Casein kinase iδ Mutations in Familial Migraine and Advanced Sleep Phase] .Science Transitional Mag. 2013 May 1; 183(5):183ra56.

He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis. Science. 2009 325:866.

Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, Fu YH. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 5; 17(2):291-302. ; .

参见

  • 睡眠的神经科学

参考文献
外部链接

#美國遺傳學家 #台灣裔美國科學家 #美国国家科学院院士 #中央研究院生命科學組院士 #國立中興大學農業暨自然資源學院校友 #华裔美国生物学家 #俄亥俄州立大學校友 #傅姓 #台灣生物學家 #豐原區人 #臺灣遺傳學家 #加州大學舊金山分校教師 #美国女性生物学家 #女性遺傳學家

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