坦度螺酮

{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 470477293
| IUPAC_name = (1R,2R,6S,7S)-4-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-4-azatricyclo[5.2.1.02,6]decane-3,5-dione
| image = Tandospirone.svg
| width = 250
| alt =

| tradename = Sediel
| Drugs.com =
| pregnancy_category =
| legal_status = Rx-only
| routes_of_administration = 口服给药

| bioavailability =
| metabolism =
| metabolites =
| elimination_half-life = Tandospirone: 2–3 hours
: 3–5 hours
| excretion = Urine (70%; 0.1% as unchanged drug)

| CAS_number_Ref =
| CAS_number = 87760-53-0
| ATC_prefix = none
| ATC_suffix =
| PubChem = 91273
| IUPHAR_ligand = 55
| ChemSpiderID_Ref =
| ChemSpiderID = 82421
| UNII_Ref =
| UNII = 190230I669
| ChEBI = 145673
| ChEMBL_Ref =
| ChEMBL = 274047
| synonyms = Metanopirone

| C=21 | H=29 | N=5 | O=2
| SMILES = O=C1N(C(=O)[C@H]3[C@@H]1[C@@H]2CC[C@H]3C2)CCCCN5CCN(c4ncccn4)CC5
| StdInChI_Ref =
| StdInChI = 1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-
| StdInChIKey_Ref =
| StdInChIKey = CEIJFEGBUDEYSX-FZDBZEDMSA-N
}}
坦度螺酮（），是一款在中國與日本經常被用作為抗焦虑药與抗抑鬱藥的藥物。坦度螺酮為氮哌酮，哌嗪一員，化學結構上與丁螺環酮相似。

1. 药理作用

坦度螺酮主要通过选择性作用于脑内的5-羟色胺1A（5-HT1A）受体来发挥其抗焦虑效果。它主要作用于情感中枢，如海马和杏仁核，通过调节5-HT的释放和受体活性来减轻焦虑症状，而不影响其他神经递质系统，因此具有较少的镇静和肌肉松弛副作用

2.适应症

神经症所致的焦虑状态：如广泛性焦虑症、躯体疾病伴发的焦虑状态：如原发性高血压、消化性溃疡等躯体疾病伴随的焦虑症状。
参考文献