{{Infobox U.S. county
| state = Kentucky
| county = Nicholas County
| county_zh = 尼古拉斯縣
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| founded =
| named for = Thomas Nelson, Jr. (1738–1789), signer of the Declaration of Independence.
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| area_total_km2 = 510
| area_total_sq_mi = 197
| area_land_km2 = 509
| area_land_sq_mi = 197
| area_water_km2 = 1
| area_water_sq_mi = 0
| area percentage = 0.12%
| census yr = 2000
| census estimate yr =
| pop = 6,813
| population_density_km2 = 13
| population_density_sq_mi = 35
| time zone = Eastern
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| coordinates = {{coord|{}|0|N|{}|0|W|type:adm2nd|display=title,inline}}
}}
尼古拉斯縣()是美國肯塔基州北部的一個縣。面積510平方公里。根據美國2000年人口普查,共有人口6,813人。縣治卡萊爾 (Carisle)。
成立於1799年,縣政府成立於1800年6月1日。本縣紀念肯塔基州州憲法起草者之一、有「州憲之父」之稱的喬治·尼古拉斯(George Nicholas)。
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