信号转导接头蛋白或信号转导衔接蛋白（）是信号转导通路中的重要蛋白质。接头蛋白上有着各种能与其它蛋白结合的结构域，能形成各种信号复合体。这些蛋白质往往本身缺乏酶的活性，而是通过特异性的蛋白-蛋白交互作用形成蛋白质复合体来激活下游信号通路。常见的接头蛋白有MyD88、Grb2和SHC1等。
基因
编码接头蛋白的基因有：
- BCAR3 – Breast cancer anti-estrogen resistance protein 3
- GRAP – GRB2-related adaptor protein
- GRAP2 – GRB2-related adaptor protein 2
- LDLRAP1 – low-density lipoprotein receptor adaptor protein 1
- NCK1 – NCK adaptor protein 1
- NCK2 – NCK adaptor protein 2
- NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein
- PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1
- SH2B1 – SH2B adaptor protein 1
- SH2B2 – SH2B adaptor protein 2
- SH2B3 – SH2B adaptor protein 3
- SH2D3A -SH2 domain containing 3A
- SH2D3C – SH2 domain containing 3C
- SHB – Src homology 2 domain containing adaptor protein B
- SLC4A1AP – solute carrier family 4 (anion exchanger), member 1, adaptor protein
- GAB2 – GRB2-associated binding protein 2
参考文献
延伸阅读
*TAB2 is an adaptor protein involved in the IL-1 signal transduction pathway:
*Good article about adaptor proteins involved in protein kinase C-mediated signal transduction:
*A good article regarding the role of adaptor proteins involved with the T-cell antigen receptor:
*Signalling discussed with regards to adaptor proteins:
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