佐米曲普坦

{{Drugbox
| Watchedfields = changed
| verifiedrevid = 477869605
| IUPAC_name = (S)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one
| image = Zolmitriptan Structure V.1.svg
| width = 250
| image2 =
| width2 = 120

| tradename = Zomig
| Drugs.com =
| pregnancy_AU = B3
| pregnancy_US = C
| legal_US = Rx-only
| routes_of_administration = Oral, nasal spray

| bioavailability = 40% (oral)
| protein_bound = 25%
| metabolism = Hepatic (CYP1A2-mediated, to active metabolite)
| elimination_half-life = 3 hours
| excretion = Renal (65%) and fecal (35%)

| CAS_number_Ref =
| CAS_number = 139264-17-8
| ATC_prefix = N02
| ATC_suffix = CC03
| ATC_supplemental =
| PubChem = 60857
| IUPHAR_ligand = 60
| DrugBank_Ref =
| DrugBank = DB00315
| ChemSpiderID_Ref =
| ChemSpiderID = 54844
| UNII_Ref =
| UNII = 2FS66TH3YW
| KEGG_Ref =
| KEGG = D00415
| ChEBI_Ref =
| ChEBI = 10124
| ChEMBL_Ref =
| ChEMBL = 1185

| C=16 | H=21 | N=3 | O=2
| smiles = O=C1OCC@@HCc2ccc3c(c2)c(cn3)CCN(C)C
| InChI = 1/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
| InChIKey = ULSDMUVEXKOYBU-ZDUSSCGKBB
| StdInChI_Ref =
| StdInChI = 1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
| StdInChIKey_Ref =
| StdInChIKey = ULSDMUVEXKOYBU-ZDUSSCGKSA-N
}}
佐米曲普坦 （）是一种选择性5-HT1激动剂，通过激动颅内血管（包括动静脉吻合处）和三叉神经系统交感神经上的5-HT1B/1D受体，引起颅内血管收缩并抑制前炎症神经肽的释放，从而作为一种治疗偏头痛和丛集性头痛的曲坦类药物。

说明
佐米曲普坦是一种人工合成的色胺衍生物，白色粉末，易溶于水。

参考文献
*

外部链接
*[http://www.zomig.com Zomig Information Site (USA)]