酮康唑

{{Drugbox
|verifiedrevid = 457114462
|IUPAC_name = 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
|image = Ketoconazole2.png
|width = 300
|image2 = Ketoconazole 3D balls 1jin.png
|width2 = 200

|tradename = Nizoral
|Drugs.com =
|MedlinePlus = a682816
|pregnancy_AU = B3
|pregnancy_US = C
|legal_UK = POM
|legal_US = OTC
|routes_of_administration = Oral, topical
|licence_US = Ketoconazole

|bioavailability = Variable
|protein_bound = 84 to 99%
|metabolism = Hepatic
|elimination_half-life = Biphasic:
|excretion = Biliary and renal

|CASNo_Ref =
|CAS_number_Ref =
|CAS_number = 65277-42-1
|ATC_prefix = J02
|ATC_suffix = AB02
|ATC_supplemental =
|PubChem = 456201
|IUPHAR_ligand = 2568
|DrugBank_Ref =
|DrugBank = DB01026
|ChemSpiderID_Ref =
|ChemSpiderID = 401695
|UNII_Ref =
|UNII = R9400W927I
|KEGG_Ref =
|KEGG = D00351
|ChEBI_Ref =
|ChEBI = 48336
|ChEMBL_Ref =
|ChEMBL = 75

|C=26 |H=28 |Cl=2 |N=4 |O=4
|smiles = O=C(N5CCN(c4ccc(OC[C@@H]1OC@(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C
|InChI = 1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
|InChIKey = XMAYWYJOQHXEEK-OZXSUGGEBE
|StdInChI_Ref =
|StdInChI = 1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
|StdInChIKey_Ref =
|StdInChIKey = XMAYWYJOQHXEEK-OZXSUGGESA-N
}}

酮康唑（）又称里素劳、康特、酶康灵、尼唑拉、酮基咪唑等，化学名称为1-乙酰基-4-〔4-〔2-（2，4-二氯苯基）-2（1H-咪唑-1-甲基）-1，3-二氧戊环-4-甲氧基〕苯基〕-哌嗪，CAS号65277-42-1。

酮康唑为合成的咪唑二烷衍生物，对皮真菌、酵母菌（包括念珠菌属、糠秕孢子菌属、球拟酵母菌属、隐球菌属）、双相真菌和真菌纲具有抑菌和杀菌活性，临床用于治疗深部和浅部真菌病，包括胃肠道真菌感染、局部用药无效的阴道白色念珠菌病、皮肤真菌感染、白色念珠菌、球孢子菌等。有限的临床研究表明含酮康唑洗发水亦可抑制脱发。

参考文献