奥美沙坦

{{drugbox
| verifiedrevid = 408738535
| drug_name= Olmesartan medoxomil
| IUPAC_name = (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate
| image = olmesartan.png
| ChemSpiderID_Ref =
| ChemSpiderID = 115748
| UNII_Ref =
| UNII = 6M97XTV3HD
| InChI = 1/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
| InChIKey = UQGKUQLKSCSZGY-UHFFFAOYAJ
| StdInChI_Ref =
| StdInChI = 1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
| StdInChIKey_Ref =
| StdInChIKey = UQGKUQLKSCSZGY-UHFFFAOYSA-N
| CAS_number_Ref =
| CAS_number = 144689-63-4
| ATC_prefix = C09
| ChEMBL_Ref =
| ChEMBL = 1516
| ATC_suffix = CA08
| ATC_supplemental =
(with diuretics)
(with amlodipine)
| PubChem = 130881
| DrugBank = APRD00223
| C=29 | H=30 | N=6 | O=6
| smiles = O=C1O/C(=C(\O1)C)COC(=O)c2c(nc(n2Cc5ccc(c4ccccc4c3nnnn3)cc5)CCC)C(O)(C)C
| bioavailability = 26%
| protein_bound =
| metabolism = Hepatic (cannot be removed by hemodialysis)
| elimination_half-life = 13 hours
| pregnancy_category = C级 (D级 如果患者是第二或第三胎)
|legal_status = 处方药
|routes_of_administration = 口服
| excretion = 肾 40%, 胆道 60%
}}
奥美沙坦（ (商品名：Benicar (美国)、Olmetec (欧洲)) 是一款血管紧张素II受体拮抗剂药物，用于治疗高血压症。 前体药物奥美沙坦酯在国际市场上以日本第一三共制药生产的品牌、印度基达斯卡迪拉公司（Zydus Cadila）生产的Olmy牌 以及印度兰伯西实验室有限公司生产的Olvance品牌。

适应症
奥美沙坦适用于治疗高血压症，可以单独服用也可与其他抗高血压药物组合服用以达到降压效果，也可应用于马歇尔医疗方案（Marshall Protocol）。
参考资料
外部链接
*[http://www.benicar.com/ Daiichi-Sankyo Benicar page]
*[http://www.rxlist.com/benicar-hct-drug.htm Benicar HCT] from RXlist.com